Best Serum for Hormonal Acne in 2023

Best Serum for Hormonal Acne
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Serums for hormonal acne and hormonal breakouts have gained popularity in recent years, and for a good reason. However, choosing the right serum for your skin can be challenging. Acne is a common skin condition, but it requires the right kind of treatment. Even though all serums have the same purpose, not all are equally effective, have high-quality ingredients, or are suitable for all skin types.

Therefore, we’ve compiled a list of the best serum for hormonal acne. Read on to find out which one is best for you.

If you’re wondering if vitamin C serum helps with acne, check out this article.

Comparison Chart

Neutrogena Hydro Boost Hydrating Hyaluronic Acid Serum, Oil-Free and Non-Comedogenic Formula for Glowing Complexion, 1 fl. oz
41Ybv+0a7wS. SL500
InstaNatural Niacinamide 5% Face Serum – Vitamin B3 Anti Aging Skin Moisturizer – Diminishes Breakouts, Wrinkles, Lines, Age Spots, Hyperpigmentation, Dark Spot Remover for Face – 2 oz
315tCviI6HL. SL500
Mario Badescu Anti-Acne Serum, 1 Fl Oz
41I9+2DiW9L. SL500
DERMA E Acne Blemish Control Treatment Serum – Active Salicylic Acid Serum for Face – Pore-Cleaning Anti-Blemish and Blackhead Treatment for Blemish-Prone Skin, 2 fl oz
41CxY5yl +S. SL500
Bliss Clear Genius Clarifying Toner + Serum | Purifies Pores, Tones, Calms & Clears Skin | with Salicylic Acid, Niacinamide & Witch Hazel | Clean | Cruelty Free | Paraben Free | Vegan | 4.3 oz

Best Serum for Hormonal Acne: Reviews

Neutrogena® Hydro Boost Hydrating Serum

best serum for hormonal acne

Neutrogena’s Hydra Boost Serum is a light serum with hyaluronic acid and olive leaf extract, which are believed to increase skin hydration by up to 300% in just one hour, thus making it one of the best skin care products out there. In addition, this non-greasy serum is non-comedogenic, oil-free, and alcohol-free, which is excellent for anybody with hormonal acne and regular hormonal breakouts.


Neutrogena Hydro Boost has a familiar consistency and texture, almost like a moisturizer. Thus, you can use the serum as a moisturizer or apply it before applying your usual moisturizer. In addition, the serum is easy to apply and work with because it doesn’t leave a greasy residue or sticky feeling. It also helps to control your skin’s oil production. 

Two pumps of Neutrogena Hydro Boost are all you need for full coverage on the face and neck. You can use the serum every morning and evening after cleansing and drying your face. Once the serum has been fully absorbed, follow up with a moisturizer, if you wish, and any other products you want to use. You can also use it as a base for makeup since the serum has a water base that won’t affect your makeup look.

The product totally absorbs into the skin in about 15 seconds. It doesn’t feel like you applied anything on your face once dry, yet you still will have hydrated and well-cared-for skin.

If you’re allergic to particular aromas or prefer to use scentless products, Neutrogena Hydro Boost moisturizing face serum is a great option. This is also a big plus for hormonal acne since there are no artificial aromas that could irritate your skin. It’s a product that should result in healthy skin in a very limited amount of time. 

The Neutrogena Hydro Boost moisturizer will make a difference to your skin’s general hydration and texture when used over a more extended period.

Although Neutrogena Hydro Boost face serum is on the cheaper end of the spectrum at around $15 at the time of writing, it certainly gets the job done. This serum has many positive aspects, from how it feels on the skin to the ease of wearing it under makeup.

However, even though the product boasts hyaluronic acid, this isn’t the main hydrator in the serum. Glycerin, yeast extract, plant-derived sugars xylitol, aylitylglucoside, panthenol (vitamin B5), and anhydroxylitol are more crucial for hydration in this serum. This formula is more than just a one-note performer, thanks to the inclusion of these ingredients.


  • The dehydration-quenching, silky texture glides on easily.
  • Doesn’t leave a sticky and tacky feeling once it dries.
  • Has a great mix of hydrating ingredients.
  • Layers well under products like moisturizers, makeup, and others.
  • Fragrance, oil, and alcohol-free.
  • Helps prevent excessive oil production.


  • Hyaluronic acid isn’t the main hydrator.
  • Tested on animals.

InstaNatural Niacinamide Serum

best serum for hormonal acne

The InstaNatural Niacinamide, 5% Serum, claims to lessen the appearance of spots and hyperpigmentation and smooth out fine lines and wrinkles by regulating your skin’s natural oils. Because this product contains a variety of naturally derived components, it is suitable for even the more sensitive skin types and can help reduce and control active breakouts. 


Ingredients such as niacinamide, vitamin E, hyaluronic acid, rosemary extract, and avocado oil are essential components of this serum. The amounts of acids in this serum allow for great advantages. The combination tightens and nourishes the skin simultaneously. Acne, UV damage, and hyperpigmentation can all be reduced thanks to its inclusion of vitamin B3.

Not only that, but InstaNatural’s goal is to design products that take advantage of the health benefits that natural, botanical components have to offer. This company is cruelty-free and uses no synthetic colors or hazardous substances in the composition of its cosmetics and skincare products.

After cleansing and drying your skin, apply a few drops of serum straight to the skin or 4-5 drops into your palms and gently massage the entire area with your fingertips. Follow up with your preferred moisturizer once the product has been completely absorbed. It’s recommended to try it out once a day at first to see how your skin reacts. If you feel a burning in your skin, stop using the product immediately.

This serum can be used on all skin types, from dry to oily and even sensitive. On the other hand, normal to dry skin should benefit the most and experience the best benefits. Keep in mind that it should also be perfectly fine to use no matter your skin tone. 

In addition, you can expect a decrease in the number of breakouts and even cystic breakouts, less obvious acne scars, a noticeable reduction in the number of wrinkles and fine lines on the face, skin that appears fuller and firmer, decreased visibility of sun damage, inflammation, and hyperpigmentation. It can also help produce a protective skin barrier for added benefits, and even help reduce the appearance of fading acne scars. 


  • All-in-one product that tackles multiple skin issues at the same time
  • Has the ability to help reduce cystic pimples 
  • Contains natural ingredients
  • All skin types, including mature skin, can use this product.
  • Cruelty-free
  • Easy to incorporate into a daily skincare regime. 


  • A stinging feeling is possible when this product is applied.
  • Can cause the skin to feel sticky to the touch if it is not adequately moisturized.

Mario Badescu Anti Acne Serum

best serum for hormonal acne

The Mario Badescu Anti Acne Serum acts as an acne preventative to avoid breakouts. The salicylic acid in this treatment prevents microorganisms from creating pimples. In addition, its non-drying gel formula is quickly absorbed by the skin and helps maintain a clear and flawless complexion.


The serum prevents acne eruptions before they start with ingredients such as salicylic acid. It also helps prevent making current acne worse. Then, every evening, a thin layer spread over acne-prone areas will keep your skin smooth and clear. Moreover, it will not irritate erupted or sensitive skin.

To use the product, apply a thin layer to clean skin and all acne-prone areas on the face. It’s recommended to use the product in the evening before going to sleep.

The serum has a gel consistency that doesn’t burn when applied. The serum is meant for combination and oily skin. In addition, you can find the unique blend of ingredients on the back of the bottle that make this product a must-have for acne sufferers who wish to minimize the frequency and severity of breakouts.

The serum incorporates antibacterial and antiseptic properties. In addition, the ingredients help dissolve dead skin cells and reduce clogged pores, which improves the clarity and texture of the skin.


  • Salicylic acid is the main ingredient.
  • Helps treat a variety of skin conditions
  • Leaves the skin clear and smooth
  • Doesn’t burn
  • For combined, oily, and acne-prone skin


  • Doesn’t work as an acne treatment; only for acne prevention.
  • Takes a longer time to see results.

DERMA E Acne Blemish Control Treatment Serum

best serum for hormonal acne

Formulated using salicylic acid with a particular anti-blemish complex made of tea tree oil, relaxing lavender willow bark extract, and chamomile, this acne-fighting serum assists in unclogging pores providing healthier and cleaner-looking skin.


This acne serum is a great skin care product can help you get rid of blackheads, blemishes, and outbreaks. It contains salicylic acid, an acne-fighting beta-hydroxy acid. Combining it with our exclusive Anti-Blemish Complex, which includes willow bark extract, tea tree oil, and relaxing lavender and chamomile, maximizes its effectiveness.

Acne-prone skin benefits from this home remedy for unclogging pores, which leads to clearer, younger-looking skin. Adult acne sufferers would benefit greatly from this treatment because it works to prevent breakouts in the first place.

It can help control blemishes, particularly those caused by cystic acne, so your skin appears clearer and more radiant. It’s a rather perfect treatment for dull skin. The Anti-Acne line’s four-week consumer testing found that 96% of participants saw a decrease in blemishes after using this treatment, making it an essential part of our adult acne product range.

The skin should be cleansed entirely before applying the product. First, apply a thin layer of serum to the entire affected area one to three times a day. Start with one application a day and progressively increase to two to three times a day, or as prescribed by your doctor. Reduce serum use to once or twice a week if dryness or peeling is a problem.

Salicylic acid is the active ingredient, a beta-hydroxy acid that facilitates the shedding of dead skin cells. Tea tree oil, willow bark extract, calming lavender, and chamomile make up the anti-blemish complex, which helps unclog pores and minimize redness.

Green tea is a source of antioxidants that can protect the skin from environmental toxins and sun damage. In addition, Aloe vera is a plant-based component known to alleviate skin rashes.


  • Helps to combat blackheads, acne, and cystic acne
  • Helps prevent future breakouts from occurring
  • Vegan, gluten and soy-free, and cruelty-free
  • Salicylic acid is the main ingredient.
  • Can help make skin plump. 
  • Easily incorporated into an existing skincare regime. 
  • Plant-based ingredients
  • Some ingredients can help increase collagen production


  • Can cause peeling and slightly irritated skin 
  • Not for dry skin

Bliss Clear Genius Clarifying Toner + Serum

best serum for hormonal acne

This revolutionary therapy exfoliates, tightens, and hydrates while simultaneously delivering potent active ingredients using a toner and serum in one step.


According to the company’s website, the toner + Serum Clarity, 5 Complex from Bliss is “clinically proven to create clear, tranquil skin in two weeks.” However, this bold claim is unlikely to hold true for most users.

This Clear Genius serum must be stored in a dark location to prevent the breakdown-prone chemicals from being exposed to light. Just push the circular disc on the top of the cap to release the thin gel, which can be easily applied to the face. If you’d like, you can use a moisturizer afterward. If your skin is dry, you’ll need a moisturizer. People with oilier skin may be able to get by without one.

Butylene glycol, a moisture-binding ingredient, niacinamide, a barrier-replenishing ingredient, and sodium hyaluronate are hydrating ingredients. However, your skin will also receive some unusual yet beneficial ingredients like tea tree oil and witch hazel water, the former of which has a medicinal scent that disappears quickly.

The water form of witch hazel is less irritating than the extract form since it is more diluted. It’s also worth noting that the aroma of tea tree oil isn’t solid or lingering, so it shouldn’t be too bothersome.

This product contains beta-hydroxy acid (BHA) salicylic acid. However, this anti-acne component would not be able to perform well because the Ph of the formula is 5.5, which is too high.

When it comes to clearing up acne, other kinds of zinc seem to work better, but this isn’t the case here. On the other hand, Zinc PCA is well-known for its anti-aging, soothing, and hydrating properties. This is an excellent product. However, it doesn’t meet the brand’s claims of clear skin.

Citrus aurantifolia, also known as Centella Asiatica leaf, is an anti-inflammatory antioxidant found in this product, along with sodium hyaluronate, rosehip oil, lentil seed, and willow bark. Together, these components help fulfill the product’s promise of being a serum and toner. However, there are better ingredient lists, so you should use different products to get the best results.


  • The thin gel texture is suitable for all types of skin.
  • Ideal for spot treatment and large pimple patches
  • This toner has a potent combination of ingredients commonly found in high-quality toners.
  • For oily skin, it’s a stand-alone hydrator.


  • A clear complexion after two weeks is highly unlikely.
  • Salicylic acid cannot unclog pores or cleanse skin at this pH level.
  • Irritation of the skin is a possible side effect of using witch hazel or tea tree oil.


When it comes to serums that will hydrate the skin without irritating and causing more acne, the Neutrogena® Hydro Boost Hydrating Serum is our top pick. This serum is excellent for all skin types and will hydrate the skin without leaving any greasy residues, and is fantastic for preventing and controlling acne breakouts. Moreover, you won’t even need a moisturizer if you have oily skin.

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